At Bristol Myers Squibb we are inspired by a single vision transforming patients lives through science. In oncology hematology immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. Job Description We seek a collaborative and innovative computational scientist with strong background in predictive leverage of biological pathways and networks to join the Predictive Sciences team in San Diego and contribute to development of transformative therapies in cancer and hematological malignancies. This role will involve work alongside a group of computational biologists machine learning researchers and data engineers who collaborate closely with scientists in the Oncogenesis Thematic Center of Excellence to focus on advancing novel therapies into the clinic. This role offers the opportunity to directly impact origination and development of novel therapies in key diseases of unmet medical need by leveraging targeted protein degradation a novel approach to address previously intractable disease targets. The successful candidate will contribute to design and lead analysis of molecular profiling experiments for target validation mechanism of action and biomarker identification using both preclinical and clinical datasets. Keen interest and hands-on experience in the development and application of network and systems biology approaches to generate and test actionable hypothesis is imperative. Responsibilities Develop and apply leading-edge network and systems biology approaches to integrate heterogenous datasets from internal public and partner sources Collaborate as a member of cross functional teams to design analyze and interpret genomics epigenetics and proteomics experiments for elucidating mechanisms of drug sensitivity and resistance and prioritizing synergistic combinations. Perform analysis of multi-modal clinical and preclinical genomic datasets using integrative network based approaches to identify disease molecular subtypes driver mechanisms and novel targeting opportunities. Translate mechanistic findings and signatures from preclinical models to clinical application. Author scientific reports and present methods results and conclusions to publishable standard. Contribute to planning and execution of collaborative projects with leading academic and commercial research groups worldwide. Background experience & complementary knowledge Ph.D. in computational biology bioinformatics biostatistics or related field from a recognized higher-education establishment. 2+ years of post-doctoral experience in applying quantitative approaches to solve biological problems in university hospital pharma or biotech research environments. Broad experience in analyzing as well as generating actionable insights from gene expression and other high-throughput molecular profiling data. Demonstrated ability to integrate heterogeneous data sources and perform predictive multivariate analysis of integrated high-dimensional datasets. Familiarity with human interactome resources and databases (e.g. PPI regulatory networks metabolic networks) and experience with machine learning and/or network-based modeling approaches. Expertise in algorithmic implementation statistical programming and data manipulation using e.g. R/Bioconductor Python and contemporary open-source bioinformatics tools and databases using readable and reproducible code. Track record of peer-reviewed publications in top-tier scientific journals. Proven problem-solving skills collaborative nature and adaptability across disciplines. Excellent verbal and written communication skills. Fluent verbal and written English language skills prerequisite. Around the world we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture our shared values of passion innovation urgency accountability inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives. Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration innovation productivity employee well-being and engagement and enhances the Company culture. To protect the safety of our workforce customers patients and communities the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19 unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S. Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief during or any part of the recruitment process please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
