Job Posting Description At Boston Children’s Hospital, success is measured in patients treated, parents comforted and teams taught. It’s in discoveries made, processes perfected, and technology advanced. In major medical breakthroughs and small acts of kindness. And in colleagues who have your back and patients who have your heart. As a teaching hospital of Harvard Medical School, our reach is global and our impact is profound. Join our acclaimed team and discover how your talents can change lives. Yours included. The Bauer lab at Boston Children’s Hospital is looking for candidates excited about computational challenges in CRISPR genome editing, chromatin biology and single-cell analysis. The Bauer lab develops and applies functional genomics methods to investigate gene regulatory mechanisms and networks that contribute to health and disease and to develop innovative therapeutics. The lab has identified favorable targets for therapeutic genome editing for the ?-hemoglobinopathies, now being investigated in clinical trials; elucidated molecular mechanisms of hemoglobin switching; advanced high-throughput gene editing approaches to associate genetic variants with phenotypes; and developed methods for highly efficient and specific gene editing in human hematopoietic stem cells. Read more about our research, publications and software here: bauerlab.org and pinellolab.org. Our labs are committed to diversity and equality; therefore, we encourage applications from underrepresented minorities. The Bioinformatician I will be responsible for: Working on projects developing innovative computational approaches to systematically analyze bulk and single-cell CRISPR perturbation experiments and integrate transcriptome, epigenome, proteome, and genome structural datasets to investigate gene regulatory networks. Interfacing closely with the Pinello lab at Massachusetts General Hospital which uses machine learning, data mining and high-performance computing technologies such as parallel and GPU computing to solve computationally challenging and Big Data problems associated with next generation sequencing (NGS) data analysis. To qualify, you must have: A degree in in Computer Science, Statistics, Genetics, Bioinformatics, Computational Biology, Biochemistry, Biophysics, Mathematics, Physics, or related fields. Excellent communication and writing skills Able to work both independently and in teams Preferred Skills (not required) Proficiency in Python and/or R Experience with commonly used bioinformatics tools and databases. Experience working with different types of NGS data such as ChIP-seq, RNA-seq, ATAC-seq Experience in the analysis of data from genome editing assays and single cell experiments Wet-lab experience. Knowledge of commonly-used machine learning methods Web development Application process. Please note: During a public health emergency, individuals in this role may be expected to take on additional duties to respond to organizational needs. Please submit a cover letter with your application describing your current and future research interests. Boston Children’s Hospital offers competitive compensation and unmatched benefits, including a, affordable health, vision and dental insurance, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition Reimbursement, and discounted rates on T-passes (50% off). Flexible schedule (if applicable). Discover your best. Boston Children’s Hospital is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability. StatusFull-Time Regular, Temporary, Per Diem Regular Standard Hours per Week40 Office/Site Location Boston Job CategoryResearch
