Research Prime

Computational Biologist I, Center for Immuno-Oncology

Organisation Name: Dana-Ferber
Organisation Type:
City:
State:
Country: United States

Job Description:

Job ID:
28410

Location:
450 Brookline Ave Boston MA 02215

Category:
Clinical Research

Employment Type:
Full time

Work Location:
PTL Remote: 2-3 days remote/wk

Overview

The Center for Immuno-Oncology (CIO) at the Dana-Farber Cancer Institute is a multi-disciplinary group dedicated to the discovery development and first-in-human clinical trials of novel immunotherapies. The CIO utilizes cutting-edge technologies such as high-throughput RNA and DNA sequencing mass cytometry (CyTOF) immunofluorescence imaging and advanced bioinformatics methodologies and analysis.

The Computational Biology Group in the CIO is currently seeking a Computational Biologist to participate and collaborate in processing a variety of immuno-oncology assays integrating clinical data and ensuring rapid computational analysis for co-author publications. Additionally the Computational Biologist will be responsible for liaising and assisting faculty research staff and other stakeholders in the collection management analysis and interpretation of biological data with a focus on the analysis of data from genomic transcriptomic or proteomic studies.

As a member of the CIO Computational Biology Group you will also be affiliated with the Dana-Farber Department of Data Sciences. In addition to working with PIs clinicians scientists at the CIO including CIO Director Dr. F Stephen Hodi you will also be collaborating with Dr. Ethan Cerami and the Knowledge Systems Group at Dana-Farber.

Located in Boston and the surrounding communities Dana-Farber Cancer Institute brings together world renowned clinicians innovative researchers and dedicated professionals allies in the common mission of conquering cancer HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners including other Harvard Medical School-affiliated hospitals. At Dana-Farber Cancer Institute we work every day to create an innovative caring and inclusive environment where every patient family and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals neither do we.If working in this kind of organization inspires you we encourage you to apply.

Responsibilities

  • Analyze and interpret high-throughput clinical DNA and RNA sequencing data with a specific focus on immunological characterization.
  • Extract and analyze spatial data from protein immunofluorescence protein imaging data.
  • Interprets complex biological information. Performs tasks to reduce and consolidate output from software.
  • Prepares data for utilization by other scientists.
  • Retreive data from public databases and provide additional context and insight to DFCI studies.
  • Must be able to query various sources for the information needed (e.g. the Web publications internal DFCI resources).
  • Directs and guides DNA RNA and protein sequence database searches and computational analysis of resulting data.
  • Implements end-users needs in database searching and integration.
  • Excellent verbal/written communication skills and willingness to collaborate cross-departmentally.
  • Contribute to collaborative projects and co-author publications.
  • Communicate new findings in a translational research environment strongly focused on discovery and development of novel immunotherapies to improve patient care

Qualifications

  • Bachelor's degree required. MS with professional experience preferred.
  • Applied professional experience in oncology immunology or life sciences required.
  • Experience with biostatistics analysis packages and well documented analysis required.
  • Ability to write high-quality analysis code and read/review code in R and/or python required.
  • Software development skill would be a significant plus.
  • Excellent verbal/written communication skills and willingness to collaborate cross-departmentally required.
  • Familiar with the design and execution of the analysis of RNA-seq and DNA-seq (WES and WGS) pipeline from FASTQs to processed results preferred.
  • Experiences with CyTOF IHC or mIF would be a significant plus.
  • Record of academic publications or contributions to open-source software is highly encouraged.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race color religion sex gender identity or expression national origin sexual orientation genetic information disability age ancestry military service protected veteran status or other groups as protected by law.

Apply

Posting Date: Apr 11, 2022
Closing Date:
Organisation Website/Careers Page: https://careers.dana-farber.org/job/computational-biologist-i-center-for-immuno-oncology-clinical-research-boston-ma-28410/


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