Job Description:
Why Seres Therapeutics
Seres Therapeutics is a leading microbiome therapeutics platform company developing a novel class of multifunctional bacterial consortia that are designed to functionally interact with host cells and tissues to treat disease. Our SER-109 program achieved the first-ever positive pivotal clinical results for a targeted microbiome drug candidate and has obtained Breakthrough Therapy and Orphan Drug designations from the FDA. The SER-109 program is being advanced for the treatment of recurrent C. difficile infection and has potential to become a first-in-class FDA-approved microbiome therapeutic.
Seres Therapeutics is a member of the Flagship Pioneering family of companies.
Position Summary
The Computational Microbiome Sciences (CMS) group is looking for a scientific programmer to support research and clinical computational activities. The CMS group has responsibilities that extend across the range of research and clinical activities at Seres, from algorithm development, to preclinical research, including the design and subsequent clinical evaluation of therapeutic consortia.
The successful candidate will interface with scientists in CMS, and research scientists across R&D and clinical to develop computational tools and execute analyses supporting early and late stage clinical and preclinical programs. Responsibilities will include developing rigorous code and analytics for microbiome Statistical Analysis Plans in clinical trials, with a focus on statistical programming. Experience with implementing and benchmarking public bioinformatics tools and algorithms a strong plus.
This is a great opportunity to experience the biotech drug development pipeline from end to end, immerse yourself in a fast-paced and highly interdisciplinary environment, and contribute directly to an incredibly promising and emerging therapeutic field. You will also be part of a great, supportive team that emphasizes collaboration and learning new skills.
What You’ll Do
- Collaborate with team members to test and deliver production-ready software for the analysis of clinical trial data.
- Perform validation of software developed for and used in clinical trial analyses.
- Exemplify good coding practices, including version control for reproducibility and code sharing.
- Collaborate with project teams, CMS, and Bioinformatics to identify key computational needs on clinical and preclinical programs
- Apply existing and novel algorithms to multi-omic data sets, communicating results to CMS, Bioinformatics, and biologists.
- Visualize, summarize, and present results to stakeholders across the organization.
What You’ll Bring
- B.S. with 2-5 years of experience or M.S. with 0-2 years of experience in Statistics, Bioinformatics, or Computational Biology, or related quantitative field (computer science, statistics, etc.).
- Proficiency with parametric and non-parametric statistical models and tests (e.g., linear/mixed linear/logistic regression, Fisher’s exact test, etc.).
- Proficiency with statistical and/or scientific programming in R required. Additional experience with Python a strong plus.
- Programming experience in a clinical trial environment a plus.
- Experience with bioinformatic and statistical data analysis packages in R and Python (e.g., ape, vegan, MASS, lme4, DESeq2, limma, ggplot2, matplotlib, scipy, statsmodels, pandas).
- Experience with unit testing and package management in R (e.g., renv, testthat), and version control (git).
- Excellent interpersonal communication (written and verbal) and organizational skills; excellent team player.
- Excellent time management skills and commitment to delivering on team goals
Seres is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation, or any characteristic protected under applicable law. |
