Job Description:
The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto Rehabilitation Institute, Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre and the Michener Institute of Education at UHN. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of groundbreaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,600 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. Research across UHN's seven research institutes spans the full spectrum of diseases and disciplines, including cancer, cardiovascular sciences, transplantation, neural and sensory sciences, musculoskeletal health, rehabilitation sciences, and community and population health. Find out about our purpose, values and principles here. The Latner Thoracic Surgery Laboratories is a multi-PI group with diverse interests including lung transplantation, mesothelioma, and esophageal cancer. We are seeking a highly motivated computational biologist to analyze large-scale sequencing data from cancer, transplant, and other sources. This individual will work closely with a principal computational biologist, a clinician-scientist, research technicians and clinical research coordinators. Our research group has a strong focus and proven track record for translational research. The individual will be responsible for designing and performing computational analyses as directed by the principal bioinformatician, investigators or senior staff members. They will primarily maintain and develop computational pipelines for our esophageal adenocarcinoma sequencing program and lung transplant biomarker program. Meticulous record-keeping and documentation of analysis for reproducibility using workflow languages and version control is required. Additional responsibilities will include supervision of junior staff members and students Your responsibilities will include: planning, implementing and coordinating all aspects of data collection and/or analysis; participating partially or fully in initial project design, setting of research goals, selection and development of procedures; participating directly in mid-level data analysis, including application of statistical analysis techniques using standard software; performing complex data manipulations without assistance; performing data conversions (as required) without assistance or existing tools; participating directly in mid-level complexity software or data analysis/visualization method development and implementation; drawing conclusions for review and incorporation into final research reports; assisting in interpretation of results and preparation of material for presentation, publication, and/or grants; assessing literature in the field of study. Qualifications
• At minimum, Bachelor’s Degree in computer science, bioinformatics, or a related discipline
• At minimum, 6 years related experience or a Masters’ with 4 years related experience
• Familiarity with Linux and HPC computational environments
• Experience with processing high-throughput sequencing data including SNV, indels and structural variants using best practice methods
• Demonstrated experience writing reproducible analysis pipelines using a workflow language such as Snakemake
• Programming experience with Python (preferred) or R with a particular emphasis on data visualization
• Familiarity with C/C++/Rust an asset
• Basic understanding of computational algorithms
• Basic knowledge of probability and statistics an asset
• Ability to work independently on analysis pipelines and projects
• Excellent communication skills
• Willingness to work in research and clinical team environments Vaccines (COVID-19 and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code. If you are interested in making your contribution at UHN, please apply on-line. You will be asked to copy and paste as well as attach your resume and covering letter. You will also be required to complete some initial screening questions. |
