Job Description:
Job Description JOB DESCRIPTION We are seeking an exceptional highly motivated computational postdoctoral fellow to join a new team at the Broad Institute to build a Human Gene Regulation Map and link this Map to Cellular Programs. This position will be embedded in the Claussnitzer lab in close collaboration with the Lander and Engreitz labs and will seek to understand the fundamental wiring of the genome in mesenchymal stem cell lineages and build a reference atlas for discovering molecular and cellular programs underlying common genetic diseases to launch new therapeutic drug discovery programs based on these human genetic insights. We are looking for a highly creative resourceful integrative thinker to join this team to make fundamental discoveries in mapping enhancer-promoter connections in multiple mesenchymal cell lineages understanding cellular programs at large scale and developing new computational tools to help uncover mechanisms underlying metabolic disease. Specifically we are looking for candidates who can lead computational analyses of population-scale phenotypic data from high-dimensional multi-modal single cell technologies and CRISPR-based screening tools to help understand genetic regulation of cellular programs in normal and diseased states.
The Claussnitzer Laboratory is a dynamic innovative and interdisciplinary workplace and is seeking to hire an exceptional scientist who will have the opportunity to work with people in the lab as well as the wider Broad community. Candidates in this position will also have access to various new emerging technologies with the potential towards making significant scientific contributions in various disease areas. CHARACTERISTIC DUTIES
Collaborate with scientists and research associates to make fundamental discoveries about genetic variant to gene to cellular function Perform high-dimensional data analysis for single-cell RNA-sequencing single-cell ATAC-sequencing and single-cell high-content imaging data from populations scale molecular and cellular profiling efforts as well as pooled genome-wide CRISPR perturbations screens Integrate multi-modal high-dimensional data sets to infer gene regulatory networks and genetically informed cellular programs Demonstrate scientific creativity and collaboration to expand computational and theoretical capabilities into new applications and identify new research opportunities Train and mentor other lab members Make significant contributions to scientific papers and presentations Contribute to generation of computational models Manage and work with multidisciplinary team to achieve project goals
REQUIREMENTS Ph.D. in Computational Biology Computer Science Physics or related life science field Extensive experience with the analysis of biological data including high-throughput functional genomics assays ideally versatile with single-cell RNA-sequencing data and/or high-content imaging data Experience in large scale data analysis a solid understanding of genetics and genomics including epigenomics transcriptomics disease genomics and statistical genetics Strong theoretical background Track record of excellent writing skills and the ability to move projects over the finish line Proven track record of critical scientific thinking multi-tasking ability ability to integrate data from multiple disciplines and strong problem-solving skills Strong interpersonal influencing and collaboration skills to work in a team-oriented matrix environment and the ability to work through conflicts Outstanding verbal and written communication abilities Ability to adapt to and effectively manage changes in a fast paced and dynamic environment A passion for science and sense of urgency to find new medicines to benefit patients
EOE/Minorities/Females/Protected Veterans/Disabilities
All Broad employees regardless of work location must be fully vaccinated for COVID-19 by Tuesday October 12 2021. Requests for exemption for medical or sincerely held religious beliefs will be considered. #LI-DNP All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity national origin disability or protected veteran status. EEO is The Law - click here for more information Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled Check out this video for a look into our community! |
