Overview The Macosko Lab, located at the Broad Institute in the Stanley Center for psychiatrist research, is seeking an exceptional candidate for a Senior Computational Scientist position, to lead efforts to assemble a cellular atlas of the human brain, defined by cutting edge single-cell and spatial genomics techniques. The brain is composed of 100 billion cells that specialize to carry out an incredible range of functions; at present, a surprisingly large amount of this cellular specialization is unknown across the hundreds of neuroanatomical regions. Using a combination of high-throughput single-cell analysis—technology we pioneered 5 years ago with the invention of Drop-seq—along with a new technology called Slide-seq that our lab developed last year, we aim to comprehensively identify cell types in the brain, localize them to specific anatomical structures, and compare these definitions to those in nonhuman primates and mice. The Broad Institute fosters a dynamic research environment involving collaborators from top tier institutions across the Boston area. The successful candidate will gain exposure to cutting-edge science through meetings, symposia, and interactions with colleagues and collaborators. This position affords the opportunity to make a significant impact on biomedical research, leading a team of computationalists to generate a paradigm-changing dataset in neurobiology. About the Job Our lab, together with others in a large, NIH-sponsored consortium, will be generating large-scale single cell and spatial genomics datasets from mammalian brain regions. These data will need to be analyzed and integrated across regions, species, and modalities. The successful candidate will be leading these efforts. The successful candidate must have significant experience performing statistical analysis of high-dimensional datasets. The data types being analyzed are quite new (1-5 years old), and hence the deployment of new algorithms, or adaptation of algorithms from other domains of machine learning—will be essential. Experience within biology is preferred, but not required. He/She will work closely with other scientists, engineers, and collaborators as part of a multidisciplinary team within the Broad Institute, as well as with colleagues at other institutions who are participating in this large-scale, exciting NIH-sponsored effort. Characteristic Duties Maintains a leadership role in tracking projects and coordinating with team members to execute on ambitious strategic goals Plans and conducts analyses in close coordination with team members and collaborators Makes sure that deliverables for large-scale project are provided in a timely fashion Makes significant contributions to scientific publications, grants, conferences, and presentations Qualifications Ph.D. in Computational Biology, Computer Science, or related field required 5+ years of research experience (professional or otherwise) Exceptional academic and professional track record Highly motivated to work as part of multidisciplinary team Mentoring or managerial experience strongly preferred #LI-POST All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.
