Principal Scientist - Computational Biology (Inflammatory Bowel Disease)

Description:

Computational Biology and Digital Sciences is a global organization across multiple sites at Boehringer Ingelheim: Ridgefield, CT US, Biberach, Germany and Vienna, Austria. We are currently hiring a Principal Scientist, Computational Biology in Ridgefield, CT. This role will conduct computational drug discovery research in the area of Immunology & Respiratory with specific focus on Inflammatory Bowel Disease (IBD) to contribute to the discovery of First-in-Class or Breakthrough drugs. This individual will establish scientific/technology strategic priorities and leads the identification and implementation of state-of-the-art capabilities across functions within the global Discovery Research organization that have a broad impact on portfolio advancement.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees

Duties & Responsibilities:

• Develops and applies the bioinformatics-specific components of the IBD strategy, partners with TA leadership to identify the gaps in new therapeutic concepts and drives the strategic use of bioinformatics and translational data to advance IBD priorities.
• Develop and apply computational algorithms and workflow to generate therapeutic evidence and insights in the context of IBD.
• Identify, evaluate, and apply new methodologies and emerging technologies to contribute to projects on Immune & Respiratory diseases.
• Generating new therapeutic concept and biomarker studies using multi-omics data such as genetics, transcriptomics, proteomics, and spatial omics.
• Working closely with cross-functional therapeutic areas scientists to develop novel insight using in silico approaches to harness the immense power of the immune system.
• Demonstrate a high level of AAI capabilities by taking the initiative without waiting for direction, working with a sense of urgency to discover breakthrough medicines that will improve patients’ lives, sharing ideas beyond own team, and challenging the status quo.

Requirements:

• PhD in bioinformatics, computational biology, systems biology, or a similar discipline.
• Five or more years of relevant experience in drug discovery or biomedical research environment with at least two (2) years of experience in drug discovery with experience conducting projects in IBD.
• IBD specific biology expertise, as well as drug discovery knowledge preferred.
• Strong hands-on skills in relevant programming languages (e.g., R, Python, Shiny, UNIX/Linux, UNIX bash shell scripting, Nextflow), statistical software, cloud computing, visualization tools, and relevant R/Bioconductor packages.
• The successful candidate will have experience analyzing diverse datasets (multi-omics) to find relevant drug discovery targets and downstream effects on immune/stromal/epithelial cell subsets; integration of genomic/transcriptome data; analyzing scRNAseq, ATACseq, spatial transcriptomics.
• Familiarity with machine learning and deep learning and experience working with biologists to solve problems.
• Must enjoy working in a multi-disciplinary and collaborative environment.
• Ability to troubleshoot both individually and as part of a team.
• Excellent oral and written skills with the ability to communicate in an open, transparent, timely and consistent manner.
• Knowledge of the drug discovery and development process.
• Publication record in peer reviewed journals.

Eligibility Requirements:

• Must be legally authorized to work in the United States without restriction.
• Must be willing to take a drug test and post-offer physical (if required).
• Must be 18 years of age or older.
• This position will require individuals to be fully vaccinated against COVID-19 or have an approved medical or religious accommodation. Click here for more information on the vaccine mandate and COVID-19.

Who We Are:

At Boehringer Ingelheim we create value through innovation with one clear goal: to improve the lives of patients. We develop breakthrough therapies and innovative healthcare solutions in areas of unmet medical need for both humans and animals. As a family owned company we focus on long term performance. We are powered by 50.000 employees globally who nurture a diverse, collaborative and inclusive culture. Learning and development for all employees is key because your growth is our growth.

Want to learn more?  Visit boehringer-ingelheim.com and join us in our effort to make more health.

Boehringer Ingelheim is an equal opportunity global employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment, which benefits our employees, patients and communities. All qualified applicants will receive consideration for employment without regard to a person’s actual or perceived race, including natural hairstyles, hair texture and protective hairstyles; color; creed; religion; national origin; age; ancestry; citizenship status, marital status; gender, gender identity or expression; sexual orientation, mental, physical or intellectual disability, veteran status; pregnancy, childbirth or related medical condition; genetic information (including the refusal to submit to genetic testing) or any other class or characteristic protected by applicable law.