Dedicated exclusively to children and their families, The Hospital for Sick Children (SickKids) is one of the largest and most respected paediatric healthcare centres in the world. As innovators in child health, we lead and partner to improve the health of children through the integration of healthcare, leading-edge research and education. Our reputation would not have been built – nor could it be maintained – without the skills, knowledge and experience of the extraordinary people who come to work here every day. SickKids is committed to ongoing learning and development, and features a caring and supportive work environment that combines exceptionally high standards of practice.
When you join SickKids, you become part of our community. We share a commitment and determination to fulfill our vision of Healthier Children. A Better World.
Don’t miss out on the opportunity to work alongside the world’s best in paediatric healthcare.
Position Description
We are looking for a motivated and skilled computational biologist to work on projects related to Replication Repair Deficiency (RRD), hypermutation and cancer. The successful candidate will have the opportunity to join a large team studying hypermutant cancers and their response to immunotherapy approaches.
Using our large biobank and registry, our team is currently working on a number of projects which include:
Developing exciting new bioinformatics-based tests to diagnose RRD signatures in normal and malignant cells.
Investigating the prevalence and characteristics of hypermutant human cancers.
Identifying novel biomarkers associated with RRD cancers and their response to immunotherapy.
Using animal models and human-derived tissue to discover novel therapies
As our Bioinformatician and computational biologist, you will be the critical cornerstone of our research program. You will have the opportunity to lead and support with data generated by our international consortium, clinical trials and exciting mouse models. You will also get the chance to use cutting-edge tools including single cell RNAseq, ATACseq and other DNA assays. This is a fantastic opportunity to boost your bioinformatics skillset and directly see how your work can have an impact on children’s health on a global scale.
Here’s What You’ll Get to Do:
Develop your professional and scientific acumen by engaging with global collaborators and stakeholders
Run WES/WGS/RNAseq pipelines in human and mouse models from FASTQ onwards
Use your skills to help troubleshoot complex bioinformatics problems and issues
Hone your skills with large sets of genomics/genetics data related to pediatric cancer
Contribute to publishing in high-impact papers including the preparation of figures
Maintain and organize lab computing database
Work closely with the PI and other lab members to organize laboratory activities and group meetings. Supervise and mentor students.
Work with a large team of clinicians and researchers on challenging problems and benefit from an intellectually stimulating and vibrant environment.
Here’s What You’ll Need:
PhD degree, preferred
A good understanding of genetics and biological data sets
Experience running WES/WGS/RNAseq analysis pipelines from FASTQ onwards
At least 2 years of experience using high performance computing environments
Proficiency with R, python and/or any other programming languages, preferred
Familiarity with adobe illustrator, preferred
Should be a good team-player; willing to support and work with different personalities and groups, including clinicians, lab technicians, postdoctoral fellows and graduate students
Excellent written and communication skills
Strong organizational skills
Able to function independently and also collaboratively within a team
Employment Type: Temporary, Full-Time (one-year contract) with possible extension to multiple years
Our Commitment to Diversity
The children and families we care for are from a variety of communities, and so are our employees. We welcome and encourage everyone to join our organization and be part of our team.
When requested, SickKids will provide access and inclusion supports to eligible candidates to support their full engagement during the interview and assessment process. Information received related to access or inclusion will be addressed confidentially.
Thank you for your interest in joining SickKids. Only those applicants selected for an interview will be contacted. In accordance with our Hospital policy, employment at SickKids is conditional upon the Hospital’s receipt of all necessary documentation.
FOR EXTERNAL APPLICANTS ONLY: As a health care institution, our highest priority is the safety of patients, families and staff. As a result, we are adopting all prevention measures to ensure the safety of our patients, families and our staff. Therefore, any offer of employment is conditional upon you submitting proof that you have been fully vaccinated with a Health Canada or World Health Organization (WHO) approved COVID-19 vaccination as soon as possible and no later than fourteen (14) calendar days prior to the effective start date, in addition to satisfying any other condition(s) that may be set out in an offer. If a candidate fails to satisfy this condition (or any other condition(s) set out in an offer), any offer of employment shall be immediately rescinded.
How to Apply
Tip: Combine your cover letter and resume into ONE document of 20 pages or less as you cannot upload multiple documents as part of your application.
If you are still experiencing technical difficulties please email ask.hr@sickkids.ca to send us a short description of the issues you are experiencing. Please note that we will not accept resumes sent to this inbox but we are happy to respond to requests for technical assistance.
