Organisation Name: Oregon Health & Science University
Organisation Type:
City:
State:
Country:
Job Description:
Department Overview The OHSU Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. Driven by its mission to end cancer as we know it, the institute is building upon its expertise in targeted treatments for cancer as well as to advance the early detection of cancer when the disease is most treatable. The Immune Monitoring and Cancer Omics Platform (IMCO) supports the development of a robust, innovative and efficient research infrastructure for clinical trials program at OHSU and its computational research needs. This position is a member of the Immune Monitoring and Cancer Omics Services (IMCO) at the Knight Cancer Institute and will report to the director of the IMCO. It will support the IMCO platform with its data analytics needs including translational/clinical projects such as internal IITs, as well as external clients and sponsored research projects. This position will work closely with the mIHC and CyTOF operating teams and lead the development of efficient pipelines for data processing, data analysis and software development in support of the mIHC and CyTOF assays. This position will be working with exciting, highly-dimensional human data (omics, imaging, mass cytometry), following best practices such as literature currency, tool benchmarking and code sharing through GitHub. Duties include teamwork, client (industry) interaction, cross-core collaboration, data management, pipeline building, shared tool optimization, statistical analysis, custom analysis with data modeling and machine learning, and contributions to IMTA reports and marketing. This is a highly exciting opportunity, utilizing cutting edge assays and innovative analytics to interrogate cancer biology in a clinically meaningful, actionable way. Function/Duties of Position Every Knight Cancer employee is expected to embody our guiding principles: We act BOLDLY—Breakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently We SUPPORT each other—Respect leads to trust, which leads to excellence We work as a CONNECTED team — We must leverage our collective brain power to conquer cancer because no one individual can do it alone Duties Include: Collaboration: Acts as the primary contact between IMCO and the mIHC and CyTOF platforms in terms of data generation and management. Interfaces with other members of the cores to streamline data management and generation including computational requirements and analysis interpretation. Data Management: Has responsibility for understanding current and future mIHC and CyTOF data management needs. Assists in understanding current challenges in data management and participates in software infrastructure plans for improving data management process and output with the goal of synergizing and streamlining the mIHC and CyTOF analytics. Workflows: Leads the development of automated data analysis workflows for mIHC and CyTOF datasets. Investigates published approaches, adopts/enhances approaches as needed, and works with software developers to implement complete workflows that are reproducible and scalable. Tools: Uses best practice software development, data analysis and biostatistics approaches to implement analysis and visualization tools for mIHC and CyTOF. Is responsible for developing, validating, and documenting the tools developed. Report generation and Custom Analysis: Is responsible for custom analyses that arise from omics, imaging and mass spectroscopy datasets generated by or for the IMCO. Report generation and interaction with prospective internal and external clients to assure data generated reflects biologically relevant questions generated by the client. Required Qualifications Master’s degree with major courses in data analysis and biostatistics and 3 years of relevant – OR - Bachelors degree and 5 years of relevant experience Experience using code based translational data analysis and algorithm development to help translate research into clinically actionable insights Demonstrated excellence in translational research (immunology, cancer biology, flow/facs, imaging, single cell assays) Advanced skills in a high- level programming language, preferably R or Python Ability to use R statistical analysis software - good understanding of biological statistics Experience with data visualization in python or R - (R- ggplot, plotly, Rshiny; Python- Bokeh, Seaborn) Knowledge of Linux or Unix commend line, optionally with Java or C/C++, TABLEAU An understanding of machine learning, data modeling or statistical techniques, such as mixed-model regression, principal component analysis, classifier construction and validation, biomarker discovery and optimization methods Experience with architecture and tools for managing “omics data OR imaging data Ability to work independently and as part of a team while being collaborative in resolving problems Excellent communication, analytical and organizational skills, both written and verbal Ability to prioritize multiple tasks at one time Preferred Qualifications Ph.D. in data science and biostatistics 7+ years of work experience as a computational biologist, bioinformatics scientist or other data science analyst with biostatistical experience Two years team science experience in a collaborative research environment One year of hands-on experience with generation and analysis of omics and/or imaging data At least 3 years work experience in a professional, team-oriented computational biology environment High performance computing experience A passion for human data analytics and cancer treatment Additional Details Apply online. Please be sure to upload a Cover Letter and Resume/CV. All are welcome Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu. Apply for this job online Email this job to a friend Share on your newsfeed
